Subsequent childhood asthma and wheeze amongst small-for-gestational-age infants in Manitoba and India: an International Partnership Initiative

Materials and methods 1995 Manitoba Birth Cohort nested case-control study: Gestational period and birth weight were extracted from hospital records and classified as per Canadian SGA guidelines. At 8-10 years, asthma status and presence of wheeze were ascertained via pediatric allergist assessment. Parental-reported data included wheeze (ever, current [past year], or during various activities) as per International Study of Allergies and Asthma in Children (ISSAC) questionnaire, and demographic data. Bangalore Cohort: Gestational period at birth and birth weight were measured. SGA babies were classified as per World Health Organization’s SGA guidelines. At 2-7 years, presence of wheeze was ascertained via physician assessment/prescription record and ISAAC questionnaire. Asthma status was not assessed. All data were analyzed using descriptive statistics and x tests. Results In Manitoba, 725 children (56.0% boys) were assessed. Mean gestational period was 39.5 ± 2.12 weeks (non-significant [NS] differences by gender). Mean birth weight was 3.38 ± 0.64 kg; girls were significantly smaller than boys (p < 0.006). 114 (16.1%) children (54.4% boys) were SGA. At ages 9.06 ± 0.64 years, 246 (34.1%) of children (149 boys) had asthma. No associations were identified between SGA and asthma, or between SGA and wheeze, when considering both genders combined or amongst boys only. Girls who were SGA were significantly more likely to have wheeze-related sleep disturbances than girls who were non-SGA (OR 0.33; 95% CI 0.12-0.94; p < 0.03). In Bangalore, 432 children (48.0% boys) were assessed for wheeze-like symptoms. Mean gestational period was 38.68 ± 1.62 weeks and mean birth weight was 2.87 ± 0.49 kg (both NS differences between genders). Participants’ mean age was 3.78 ± 1.30 years. 130 (30.2%) children (47.7% boys) were SGA. 71 (16.4%) of children (38.4% boys) had a doctor diagnosis of wheeze. SGA children had twice the risk of developing wheeze at follow-up (OR 2.19; 95%CI 1.30-3.68; p < 0.003). After stratification by gender, these associations were only significant amongst boys (OR 3.24; 95% CI 1.44-7.31; p < 0.003).